One-Alpha 0.25 mcg is a drug based on alfacalcidol, an analogue of the active form of vitamin D. It is used for the treatment and prevention of conditions associated with impaired calcium-phosphorus metabolism, such as osteoporosis, rickets, hypoparathyroidism, and chronic renal failure.
Pharmacological properties:
• Class: vitamin D analogues
• Mechanism of action:
Alfacalcidol is a prodrug that is rapidly converted in the liver to the active form of vitamin D₃ (calcitriol). It regulates the absorption of calcium and phosphates in the intestines, increases blood calcium levels, and stimulates bone tissue mineralization.
• Main effects:
Increases blood calcium levels
Improves bone density
Regulates parathyroid hormone (PTH) secretion
Prevents and treats osteomalacia and osteoporosis.
Indications:
Vitamin D deficiency
Hypoparathyroidism
Renal osteodystrophy
Osteoporosis.
Dosage and administration:
• Usual starting dose for adults:
0.25–0.5 mcg once daily orally.
• Maintenance dose: individualized depending on blood calcium and phosphorus levels.
• In patients with chronic renal failure, monitoring calcium levels is mandatory.
• Take with a small amount of water, regardless of food intake.
