Pharmacological action:
Suppresses the activity of H⁺/K⁺-ATPase in the parietal cells of the stomach
Reduces both basal and stimulated secretion of hydrochloric acid
Facilitates the healing of ulcers and erosions
Indications for use:
Gastroesophageal reflux disease (GERD)
Erosive esophagitis
Stomach and duodenal ulcers
Zollinger-Ellison syndrome
Prevention of ulcers caused by NSAIDs
As part of Helicobacter pylori eradication therapy (in combination with antibiotics)
Method of administration:
Here is a translation of the pantoprazole dosage table for adults into Russian:
Pantoprazole dosage for adults (depending on the condition):
Medical condition Dosage regimen pantoprazole
Gastroesophageal reflux disease (GERD) 40 mg orally once a day for 8–16 weeks, or 40 mg intravenously once a day for 7–10 days, then switch to tablets
Erosive esophagitis 40 mg orally once a day for 8–16 weeks, then maintenance dose of 40 mg per dayOr 40 mg intravenously once a day for 7–10 days, then switch to tablets
Zollinger-Ellison syndrome 40 mg orally once a day, as needed up to 240 mg/dayOr 80 mg intravenously every 8–12 hours for up to 7 days, then switch to tablets
Gastric ulcer (off-label) 40 mg orally once a day for 4 weeks
Duodenal ulcer (off-label) 40 mg orally once a day for 2 weeks
Dosage for children
Doses depending on the child’s age and body weight:
Drug form Age Pantoprazole dosage Duration of treatment
Oral tablets 5 years and older 15–39 kg: 20 mg once daily≥40 kg: 40 mg once daily Up to 8 weeks
Intravenous administration 3–11 months <12.5 kg: 0.8 mg/kg once daily intravenously≥12.5 kg: 10 mg once daily intravenously Up to 7 days, then switch to tablets
1–17 years ≤15 kg: 10 mg once daily intravenously16–40 kg: 20 mg once daily intravenously>40 kg: 40 mg once daily intravenously —
Notes:
After a course of intravenous administration, it is recommended to switch to the oral form in accordance with age and body weight.
