One capsule a day after breakfast or the first meal of the day.
The capsule should not be broken or pulled apart as this may have an effect on the release of the long-acting active ingredient.
No dose adjustment is warranted in renal impairment. No dose adjustment is warranted in patients with mild to moderate hepatic insufficiency.
Contraindications:
-Hypersensitivity to the active substance or to any of the excipients.
-Orthostatic hypotension observed earlier (history of orthostatic hypotension).
-Severe hepatic insufficiency.
Precautions:
As with other al adrenoreceptors antagonists, a reduction in blood pressure can occur in individual cases during treatment with tamsulosin hydrochloride as a result of which, rarely, syncope can occur.
Before therapy with tamsulosin hydrochloride is initiated, the patient should be examined in order to exclude the presence of other conditions, which can cause the same symptoms as benign prostatic hyperplasia.
The treatment of patients with severe renal impairment (creatinine clearance of < 10 ml/min) should be approached with caution.
The initiation of therapy with tamsulosin hydrochloride in patients for whom cataract surgery is scheduled is not recommended.
Tamsulosin hydrochloride should not be given in combination with strong inhibitors of CYP3A4 in patients with poor metabolizer CYP2D6 phenotype.
Tamsulosin hydrochloride should be used with caution in combination with strong and moderate inhibitors of CYP3A4.
Pregnancy and lactation
Tamsulosin is not indicated for use in women.
Side Effects:
Ejaculation disorders have been observed in short and long term clinical studies with tamsulosin.
